Cocaine administration can be disruptive to sleep. In compulsive cocaine users, sleep disruption may be a factor contributing to relapse. The effects of cocaine on sleep, particularly those produced by low doses, have not been extensively studied. Low dose cocaine may stimulate brain reward systems that are linked to the liability of abusing of this drug. This study was designed to assess the effects of the acute administration of low to moderate cocaine doses on sleep in the rat. Polygraphic recordings were obtained from freely moving, chronically instrumented rats over a 6-h period after the administration of either cocaine (as a 2.5–10 mg/kg intraperitoneal dose) or saline. Following cocaine administration, time spent by the rats in wakefulness increased and slow wave sleep decreased in a dose-dependent manner, compared to controls. These changes lasted between 1 to 3 h following the cocaine administration. Rapid eye movement (REM) sleep was decreased during a 2- to 3-h period following the injection of 5 and 10 mg/kg doses of cocaine. In contrast, REM sleep increased during the periods 2–4 h after the administration of 2.5 and 5 mg/kg doses of cocaine. These results indicate that sleep can be significantly altered by low doses of cocaine when administered subacutely.

中文翻译：

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低剂量可卡因对自由活动大鼠快速眼动睡眠的影响

可卡因给药可能会干扰睡眠。在强迫性可卡因使用者中，睡眠中断可能是导致复发的一个因素。可卡因对睡眠的影响，尤其是低剂量产生的影响，尚未得到广泛研究。低剂量可卡因可能会刺激与滥用这种药物的责任有关的大脑奖励系统。本研究旨在评估急性给予低至中等剂量可卡因对大鼠睡眠的影响。在施用可卡因（以 2.5-10 毫克/千克腹膜内剂量）或生理盐水后的 6 小时内，从自由移动、长期使用仪器的大鼠中获得多图记录。与对照组相比，服用可卡因后，大鼠清醒时间增加，慢波睡眠减少，呈剂量依赖性。这些变化在可卡因给药后持续了 1 到 3 小时。在注射 5 和 10 毫克/公斤剂量的可卡因后的 2 至 3 小时内，快速眼动 (REM) 睡眠减少。相比之下，REM 睡眠在服用 2.5 和 5 mg/kg 可卡因后 2-4 小时内增加。这些结果表明，当亚急性给药时，低剂量的可卡因可以显着改变睡眠。