There is increasing evidence that oxidative stress may play a role in the pathophysiology of hyperemesis gravidarum. Serum paraoxonase-1 (PON-1) is a high density lipoprotein (HDL)-associated enzyme that prevents oxidative modification of low density lipoprotein. The aim of the study was to measure the serum levels of PON-1 activity in women with hyperemesis gravidarum. Thirty-four women with hyperemesis gravidarum and 31 healthy pregnant women were enrolled in the study. Serum PON-1 activity was measured spectrophotometrically. Lipid hydroperoxide (LOOH) levels were measured by iodometric assay. PON-1 activity was significantly lower and LOOH levels were significantly higher in pregnant women with hyperemesis gravidarum than in healthy pregnant women (P < 0.0001, for all). There were significant correlations between PON-1 and LOOH, triglyceride, total cholesterol, HDL, low density lipoprotein (LDL) and high sensitive C-reactive protein (HSCRP; P < 0.0001, for all). By using multiple regression analysis LDL, HDL, HSCRP and LOOH were independent determinants of serum PON-1 activity in the study. Decreased PON-1 activity might be related to increased oxidative stress and inflammation in pregnant women with hyperemesis gravidarum. Subjects with hyperemesis gravidarum might be more prone to the development of atherogenesis due to low serum PON-1 activity.

中文翻译：

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妊娠呕吐患者的对氧磷酶-1活性。

越来越多的证据表明氧化应激可能在妊娠呕吐的病理生理中起作用。血清对氧磷酶-1（PON-1）是一种高密度脂蛋白（HDL）相关的酶，可防止低密度脂蛋白的氧化修饰。这项研究的目的是测量孕妇妊娠剧吐的血清中PON-1活性水平。这项研究招募了34名妊娠剧吐妇女和31名健康孕妇。分光光度法测定血清PON-1活性。脂质过氧化氢（LOOH）水平通过碘量法测定。妊娠剧吐孕妇的PON-1活性显着降低，LOOH水平显着高于健康孕妇（P均<0.0001）。PON-1和LOOH之间存在显着相关性，甘油三酸酯，总胆固醇，HDL，低密度脂蛋白（LDL）和高敏感性C反应蛋白（HSCRP； P均<0.0001）。通过多元回归分析，LDL，HDL，HSCRP和LOOH是研究中血清PON-1活性的独立决定因素。PON-1活性降低可能与妊娠呕吐孕妇的氧化应激增加和炎症有关。由于血清PON-1活性低，妊娠剧吐的受试者可能更容易发生动脉粥样硬化。PON-1活性降低可能与妊娠呕吐孕妇的氧化应激增加和炎症有关。由于血清PON-1活性低，妊娠剧吐的受试者可能更容易发生动脉粥样硬化。PON-1活性降低可能与妊娠呕吐孕妇的氧化应激增加和炎症有关。由于血清PON-1活性低，妊娠剧吐的受试者可能更容易发生动脉粥样硬化。