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Intelligent recognitive systems in nanomedicine.
Current Opinion in Chemical Engineering ( IF 6.6 ) Pub Date : 2014-05-01 , DOI: 10.1016/j.coche.2014.02.001
Heidi Culver 1 , Adam Daily 1 , Ali Khademhosseini 2 , Nicholas Peppas 3
Affiliation  

There is a bright future in the development and utilization of nanoscale systems based on intelligent materials that can respond to external input providing a beneficial function. Specific functional groups can be incorporated into polymers to make them responsive to environmental stimuli such as pH, temperature, or varying concentrations of biomolecules. The fusion of such "intelligent" biomaterials with nanotechnology has led to the development of powerful therapeutic and diagnostic platforms. For example, targeted release of proteins and chemotherapeutic drugs has been achieved using pH-responsive nanocarriers while biosensors with ultra-trace detection limits are being made using nanoscale, molecularly imprinted polymers. The efficacy of therapeutics and the sensitivity of diagnostic platforms will continue to progress as unique combinations of responsive polymers and nanomaterials emerge.

中文翻译:

纳米医学中的智能识别系统。

基于智能材料的纳米级系统的开发和利用具有光明的前景,这些材料可以响应外部输入并提供有益的功能。可以将特定的官能团结合到聚合物中,使其对环境刺激(如 pH 值、温度或不同浓度的生物分子)做出响应。这种“智能”生物材料与纳米技术的融合导致了强大的治疗和诊断平台的发展。例如,蛋白质和化疗药物的靶向释放已经使用 pH 响应纳米载体实现,而具有超痕量检测限的生物传感器正在使用纳米级分子印迹聚合物制造。
更新日期:2014-03-12
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