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Cellular metabolism modulation in T lymphocyte immunity
Immunology ( IF 6.4 ) Pub Date : 2014-05-19 , DOI: 10.1111/imm.12321
Huanrong Liu 1 , Hui Yang , Xi Chen , Yun Lu , Zhengguo Zhang , Jian Wang , Ming Zhang , Lixiang Xue , Feng Xue , Guangwei Liu
Affiliation  

T lymphocytes are a central component, and play an important role in controlling immunity and immunological diseases. Recent studies have shown that T cell metabolism is highly dynamic and has a tremendous impact on the modulation of T lymphocyte immunity. Specific metabolic pathways meet energy and biosynthetic requirements that can support specific T cell functional activities in immunity and immunological diseases. This review summarizes the recent progresses about the modulatory role of cell metabolism in T cell development, differentiation, activation and function in immunity. These might provide new opportunities to modulate the immune responses and treat clinical immunological diseases.

中文翻译:

T淋巴细胞免疫中的细胞代谢调节

T淋巴细胞是中枢成分,在控制免疫和免疫疾病方面发挥着重要作用。最近的研究表明,T 细胞代谢是高度动态的,对 T 淋巴细胞免疫的调节具有巨大的影响。特定的代谢途径满足能量和生物合成的要求,可以支持免疫和免疫疾病中特定的 T 细胞功能活动。本综述总结了细胞代谢在T细胞发育、分化、激活和免疫功能中的调节作用的最新进展。这些可能为调节免疫反应和治疗临床免疫疾病提供新的机会。
更新日期:2014-05-19
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