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HYDROGEL-BASED NANOCOMPOSITES OF THERAPEUTIC PROTEINS FOR TISSUE REPAIR.
Current Opinion in Chemical Engineering ( IF 6.6 ) Pub Date : 2014-05-01 , DOI: 10.1016/j.coche.2013.12.009
Suwei Zhu 1 , Tatiana Segura 1
Affiliation  

The ability to design artificial extracellular matrices as cell instructive scaffolds has opened the door to technologies capable of studying cell fates in vitro and to guide tissue repair in vivo. One main component of the design of artificial extracellular matrices is the incorporation of protein-based biochemical cues to guide cell phenotypes and multicellular organizations. However, promoting the long-term bioactivity, controlling the bioavailability and understanding how the physical presentations of these proteins impacts cellular fates are among the challenges of the field. Nanotechnolgy has advanced to meet the challenges of protein therapeutics. For example, the approaches to incorporating proteins into tissue repairing scaffolds have ranged from bulk encapsulations to smart nanodepots that protect proteins from degradations and allow opportunities for controlled release.

中文翻译:

用于组织修复的治疗性蛋白质的基于水凝胶的纳米复合材料。

将人工细胞外基质设计为细胞指导支架的能力为能够在体外研究细胞命运和指导体内组织修复的技术打开了大门。人工细胞外基质设计的一个主要组成部分是结合基于蛋白质的生化线索来指导细胞表型和多细胞组织。然而,促进长期生物活性、控制生物利用度和了解这些蛋白质的物理表现如何影响细胞命运是该领域的挑战之一。纳米技术已经进步以应对蛋白质疗法的挑战。例如,
更新日期:2014-04-16
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