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Zebrafish as a model for systems biology.
Biotechnology and Genetic Engineering Reviews ( IF 3.2 ) Pub Date : 2013-08-21 , DOI: 10.1080/02648725.2013.801238
Mian Yahya Mushtaq 1 , Robert Verpoorte , Hye Kyong Kim
Affiliation  

Zebrafish offer a unique vertebrate model for research areas such as drug development, disease modeling and other biological exploration. There is significant conservation of genetics and other cellular networks among zebrafish and other vertebrate models, including humans. Here we discuss the recent work and efforts made in different fields of biology to explore the potential of zebrafish. Along with this, we also reviewed the concept of systems biology. A biological system is made up of a large number of components that interact in a huge variety of combinations. To understand completely the behavior of a system, it is important to know its components and interactions, and this can be achieved through a systems biology approach. At the end of the paper we present a concept of integrating zebrafish into the systems biology approach.



中文翻译:

斑马鱼作为系统生物学的模型。

斑马鱼为研究领域提供了独特的脊椎动物模型,例如药物开发,疾病建模和其他生物探索。斑马鱼和其他脊椎动物模型(包括人类)之间的遗传学和其他细胞网络得到了显着保护。在这里,我们讨论了在生物学的不同领域中探索斑马鱼潜力的最新工作和努力。除此之外,我们还回顾了系统生物学的概念。生物系统由大量以多种组合形式相互作用的组件组成。要完全了解系统的行为,了解系统的组成部分和相互作用非常重要,这可以通过系统生物学方法来实现。在本文的最后,我们提出了将斑马鱼集成到系统生物学方法中的概念。

更新日期:2013-08-21
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