Considerable advances have occurred in the development of tissue-engineered blood vessels (TEBVs) to repair or replace injured blood vessels, or as in vitro systems for drug toxicity testing. Here we summarize approaches to produce TEBVs and review current efforts to (1) identify suitable cell sources for the endothelium and vascular smooth muscle cells, (2) design the scaffold to mimic the arterial mechanical properties and (3) regulate the functional state of the cells of the vessel wall. Initial clinical studies have established the feasibility of this approach and challenges that make TEBVs a viable alternative for vessel replacement are identified.

中文翻译：

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血管组织工程血管 (TEBV) 的生物学和工程设计考虑因素。

在开发组织工程血管 (TEBV) 以修复或替换受损血管或作为体外药物毒性测试系统方面取得了相当大的进展。在这里，我们总结了生产 TEBV 的方法，并回顾了当前的努力，以 (1) 为内皮和血管平滑肌细胞确定合适的细胞来源，(2) 设计支架以模拟动脉机械特性和 (3) 调节血管的功能状态血管壁细胞。初步临床研究已经确定了这种方法的可行性，并确定了使 TEBV 成为血管置换可行替代方案的挑战。