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A Capacitive MEMS Viscometric Sensor for Affinity Detection of Glucose
Journal of Microelectromechanical Systems ( IF 2.7 ) Pub Date : 2009-12-01 , DOI: 10.1109/jmems.2009.2034869
Xian Huang 1 , Siqi Li 2 , Jerome Schultz 3 , Qian Wang 2 , Qiao Lin 1
Affiliation  

This paper presents a capacitively based microelectromechanical systems affinity sensor for continuous glucose monitoring (CGM) applications. This sensor consists of a vibrating Parylene diaphragm, which is remotely driven by a magnetic field and situated inside a microchamber. A solution of poly(acrylamide-ran-3-acrylamidophenylboronic acid) (PAA-ran-PAAPBA), a biocompatible glucose-sensitive polymer, fills the microchamber, which is separated from its surroundings by a semipermeable membrane. Glucose permeates through the membrane and binds reversibly to the phenylboronic acid moiety of the polymer. This results in a viscosity change of the sensing solution, causing a detectable change in the Parylene diaphragm vibration which can be measured capacitively. Experimental results demonstrate that the device is capable of detecting glucose at physiologically relevant concentrations ranging from 30 to 360 mg/dL. The response time of the sensor to glucose concentration changes is approximately 1.5 min, which can be further improved with optimized device designs. Excellent reversibility and stability are observed in sensor responses, as highly desired for long-term CGM.

中文翻译:

一种用于葡萄糖亲和检测的电容式 MEMS 粘度传感器

本文介绍了一种基于电容的微机电系统亲和传感器,用于连续血糖监测 (CGM) 应用。该传感器由振动的聚对二甲苯隔膜组成,该隔膜由磁场远程驱动并位于微室内。一种生物相容性葡萄糖敏感聚合物聚(丙烯酰胺-ran-3-丙烯酰胺苯基硼酸)(PAA-ran-PAAPBA)的溶液填充微室,该微室通过半透膜与周围环境隔开。葡萄糖透过膜并可逆地结合到聚合物的苯基硼酸部分。这会导致传感溶液的粘度发生变化,从而导致聚对二甲苯隔膜振动发生可检测的变化,可以通过电容进行测量。实验结果表明,该装置能够检测生理相关浓度范围为 30 至 360 mg/dL 的葡萄糖。传感器对葡萄糖浓度变化的响应时间约为 1.5 分钟,可以通过优化的设备设计进一步改进。在传感器响应中观察到出色的可逆性和稳定性,这是长期 CGM 非常需要的。
更新日期:2009-12-01
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