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Volatile pheromone signalling in Drosophila
Physiological Entomology ( IF 1.5 ) Pub Date : 2012-02-23 , DOI: 10.1111/j.1365-3032.2011.00813.x
Dean P Smith 1
Affiliation  

Once captured by the antenna, the male‐specific pheromone 11‐cis vaccenyl acetate (cVA) binds to an extracellular binding protein called LUSH that undergoes a conformational shift upon cVA binding. The stable LUSH–cVA complex is the activating ligand for pheromone receptors present on the dendrites of the aT1 neurones, comprising the only class of neurones that detect volatile cVA pheromone. This mechanism can explain the single molecule sensitivity of pheromone detection. The receptor that recognizes activated LUSH consists of a complex of several proteins, including Or67d, a member of the tuning odourant receptor family, Orco, a co‐receptor ion channel, and SNMP, a CD36 homologue that may be an inhibitory subunit. In addition, genetic screens and reconstitution experiments reveal additional factors that are important for pheromone detection. Identification and functional dissection of these factors in Drosophila melanogaster Meigen should permit the identification of homologous factors in pathogenic insects and agricultural pests, which, in turn, may be viable candidates for novel classes of compounds to control populations of target insect species without impacting beneficial species.

中文翻译:

果蝇中的挥发性信息素信号

一旦被天线捕获,雄性特异性信息素 11-顺式醋酸乙烯酯 (cVA) 就会与一种称为 LUSH 的细胞外结合蛋白结合,该蛋白在 cVA 结合后会发生构象转变。稳定的 LUSH-cVA 复合物是存在于 aT1 神经元树突上的信息素受体的激活配体,是唯一一类检测挥发性 cVA 信息素的神经元。这种机制可以解释信息素检测的单分子灵敏度。识别激活的 LUSH 的受体由几种蛋白质的复合物组成,包括 Or67d(调谐气味受体家族的成员)、Orco(一种共受体离子通道)和 SNMP(一种可能是抑制性亚基的 CD36 同源物)。此外,遗传筛选和重组实验揭示了对信息素检测很重要的其他因素。
更新日期:2012-02-23
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