Malaria is a serious infectious disease that causes over one million deaths yearly. It is caused by a group of protozoan parasites in the genus Plasmodium. No effective vaccine is currently available and the elevated levels of resistance to drugs in use underscore the pressing need for novel antimalarial targets. In this review, we survey omics centered developments in Plasmodium biology, which have set the stage for a quantum leap in our understanding of the fundamental processes of the parasite life cycle and mechanisms of drug resistance and immune evasion.

中文翻译：

---

疟原虫疟原虫的比较基因组学和系统生物学。

疟疾是一种严重的传染病，每年导致超过一百万人死亡。它是由一组疟原虫属的原生动物寄生虫引起的。目前没有有效的疫苗可用，并且对所用药物的耐药性水平升高强调了对新型抗疟靶点的迫切需要。在这篇综述中，我们调查了以组学为中心的疟原虫生物学发展，这些发展为我们理解寄生虫生命周期的基本过程以及耐药性和免疫逃避机制的巨大飞跃奠定了基础。