Benzimidazole and their metal analogs that can act as multimodal agent and have non-peptidic CCK-B receptor antagonist were synthesized and characterized on the basis of spectroscopic techniques such as FT-IR, NMR, FAB-MS and also evaluated for biologic efficacy. The ligands showed binding to most of the organs, known to express CCK receptors in biodistribution studies. Cholecystokinin (CCK1 and CCK2) receptor binding affinities of these analogs (IC50) are 0.802 ± 0.007 for compound C and 0.326 ± 0.012 for compound D in rat pancreatic acini. These studies have provided a new template for further development of novel agents for various related diseases.

中文翻译：

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新型苯并咪唑及其金属配合物的合成，分析和药物研究。

苯并咪唑及其可充当多峰剂并具有非肽类CCK-B受体拮抗剂的金属类似物是在诸如FT-IR，NMR，FAB-MS等光谱技术的基础上合成和表征的，并评估了其生物学功效。配体显示出与大多数器官的结合，这在生物分布研究中已知会表达CCK受体。这些类似物（IC50）的胆囊收缩素（CCK1和CCK2）受体结合亲和力在大鼠胰腺腺泡中为0.82±0.007，对于化合物D为0.326±0.012。这些研究为进一步开发各种相关疾病的新型药物提供了新的模板。