Indoor and outdoor air pollution is known to contribute to increased lung cancer incidence. This study is the first to address the contribution of home heating fuel and geographical course particulate matter (PM10) concentrations to lung cancer rates in New Hampshire, USA. First, Pearson correlation analysis and geographically weighted regression were used to investigate spatial relationships between outdoor PM10 and lung cancer rates. While the aforementioned analyses did not indicate a significant contribution of PM10 to lung cancer in the state, there was a trend towards a significant association in the northern and southwestern regions of the state. Second, case-control data were used to estimate the contributions of indoor pollution and secondhand smoke to the risk of lung cancer with adjustment for confounders. Increased risk was found among those who used wood or coal to heat their homes for more than 10 winters before the age of 18, with a significant increase in risk per winter. Resulting data suggest that further investigation of the relationship between heating-related air pollution levels and lung cancer risk is needed.

中文翻译：

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新罕布什尔州和佛蒙特州的室内外空气污染与肺癌

众所周知，室内和室外空气污染会导致肺癌发病率增加。这项研究是第一个解决家庭取暖燃料和地理路线颗粒物 (PM10) 浓度对美国新罕布什尔州肺癌发病率的影响的研究。首先，使用 Pearson 相关分析和地理加权回归研究室外 PM10 与肺癌发病率之间的空间关系。虽然上述分析并未表明 PM10 对该州肺癌的显着贡献，但该州北部和西南部地区有显着关联的趋势。其次，病例对照数据用于估计室内污染和二手烟对肺癌风险的贡献，并调整混杂因素。发现在 18 岁之前使用木材或煤为家中供暖超过 10 个冬天的人的风险增加，每个冬天的风险显着增加。结果数据表明，需要进一步调查与供暖相关的空气污染水平与肺癌风险之间的关系。