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Polarized Enhanced Backscattering Spectroscopy for Characterization of Biological Tissues at Subdiffusion Length Scales
IEEE Journal of Selected Topics in Quantum Electronics ( IF 4.9 ) Pub Date : 2012-07-01 , DOI: 10.1109/jstqe.2011.2173659
Andrew J Radosevich 1 , Jeremy D Rogers , Vladimir Turzhitsky , Nikhil N Mutyal , Ji Yi , Hemant K Roy , Vadim Backman
Affiliation  

Since the early 1980s, the enhanced backscattering (EBS) phenomenon has been well-studied in a large variety of nonbiological materials. Yet, until recently, the use of conventional EBS for the characterization of biological tissue has been fairly limited. In this study, we detail the unique ability of EBS to provide spectroscopic, polarimetric, and depth-resolved characterization of biological tissue using a simple backscattering instrument. We first explain the experimental and numerical procedures used to accurately measure and model the full azimuthal EBS peak shape in biological tissue. Next, we explore the peak shape and height dependencies for different polarization channels and spatial coherence of illumination. We then illustrate the extraordinary sensitivity of EBS to the shape of the scattering phase function using suspensions of latex microspheres. Finally, we apply EBS to biological tissue samples in order to measure optical properties and observe the spatial length scales at which backscattering is altered in early colon carcinogenesis.

中文翻译:

用于表征亚扩散长度尺度下的生物组织的偏振增强后向散射光谱

自 1980 年代初以来,增强型背向散射 (EBS) 现象已在多种非生物材料中得到充分研究。然而,直到最近,使用传统 EBS 来表征生物组织还相当有限。在这项研究中,我们详细介绍了 EBS 使用简单的反向散射仪器提供生物组织的光谱、偏振和深度解析表征的独特能力。我们首先解释了用于准确测量和模拟生物组织中完整方位角 EBS 峰形的实验和数值程序。接下来,我们探索不同偏振通道和照明空间相干性的峰形和高度依赖性。然后,我们使用乳胶微球悬浮液来说明 EBS 对散射相函数形状的非凡敏感性。最后,我们将 EBS 应用于生物组织样本,以测量光学特性并观察在早期结肠癌发生中后向散射发生改变的空间长度尺度。
更新日期:2012-07-01
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