The deep waters surrounding the coastline of the northern parts of Norway represent an exciting biotope for marine exploration. Dark and cold Arctic water generates a hostile environment where the ability to adapt is crucial to survival. These waters are nonetheless bountiful and a diverse plethora of marine organisms thrive in these extreme conditions, many with the help of specialised chemical compounds. In comparison to warmer, perhaps more inviting shallower tropical waters, the Arctic region has not been as thoroughly investigated. MabCent is a Norwegian initiative based in Tromsø that aims to change this. Since 2007, scientists within MabCent have focussed their efforts on the study of marine organisms inhabiting the Arctic waters with the long term goal of novel drug discovery and development. The activities of MabCent are diverse and range from sampling the Arctic ice shelf to the chemical synthesis of promising secondary metabolites discovered during the screening process. The current review will present the MabCent pipeline from isolation to identification of new bioactive marine compounds via an extensive screening process. An overview of the main activities will be given with particular focus on isolation strategies, bioactivity screening and structure determination. Pitfalls, hard earned lessons and the results so far are also discussed.

中文翻译：

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MabCent：挪威的北极海洋生物勘探。

挪威北部海岸线周围的深水代表了令人兴奋的海洋探索生物群落。黑暗和寒冷的北极水域产生了一个恶劣的环境，在这种环境中，适应能力对生存至关重要。尽管如此，这些水域还是丰富的，而且种类繁多的海洋生物在这些极端条件下茁壮成长，其中许多是在特殊化合物的帮助下。与更温暖、或许更诱人的较浅热带水域相比，北极地区还没有得到彻底的调查。MabCent 是位于特罗姆瑟的挪威倡议，旨在改变这一点。自 2007 年以来，MabCent 的科学家们一直致力于研究居住在北极水域的海洋生物，其长期目标是发现和开发新药。MabCent 的活动多种多样，范围从北极冰架取样到筛选过程中发现的有希望的次级代谢物的化学合成。当前的审查将展示 MabCent 管道，从分离到通过广泛的筛选过程识别新的生物活性海洋化合物。将概述主要活动，特别关注分离策略、生物活性筛选和结构确定。还讨论了陷阱、来之不易的教训和迄今为止的结果。将概述主要活动，特别关注分离策略、生物活性筛选和结构确定。还讨论了陷阱、来之不易的教训和迄今为止的结果。将概述主要活动，特别关注分离策略、生物活性筛选和结构确定。还讨论了陷阱、来之不易的教训和迄今为止的结果。