Nanomedicine, the use of nanotechnology for biomedical applications, has potential to change the landscape of the diagnosis and therapy of many diseases. In the past several decades, the advancement in nanotechnology and material science has resulted in a large number of organic and inorganic nanomedicine platforms. Silica nanoparticles (NPs), which exhibit many unique properties, offer a promising drug delivery platform to realize the potential of nanomedicine. Mesoporous silica NPs have been extensively reviewed previously. Here we review the current state of the development and application of nonporous silica NPs for drug delivery and molecular imaging.

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用于纳米医学应用的无孔二氧化硅纳米颗粒

纳米医学是将纳米技术用于生物医学应用，有可能改变许多疾病的诊断和治疗格局。在过去的几十年里，纳米技术和材料科学的进步催生了大量的有机和无机纳米医学平台。二氧化硅纳米颗粒（NP）具有许多独特的特性，为实现纳米医学的潜力提供了一个有前途的药物输送平台。介孔二氧化硅纳米颗粒之前已被广泛综述。在这里，我们回顾了用于药物输送和分子成像的无孔二氧化硅纳米粒子的开发和应用的现状。