Qing Hua Chang Yin exerts therapeutic effects against ulcerative colitis through the inhibition of the TLR4/NF-κB pathway.,International Journal of Molecular Medicine

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Qing Hua Chang Yin exerts therapeutic effects against ulcerative colitis through the inhibition of the TLR4/NF-κB pathway.
International Journal of Molecular Medicine ( IF 5.4 ) Pub Date : 2013-08-01 , DOI: 10.3892/ijmm.2013.1458
Xiao Ke ₁ , Fan Zhou , Youliang Gao , Bingying Xie , Guanghong Hu , Wenyi Fang , Jun Peng , Youqin Chen , Thomas J Sferra

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The activation of the Toll-like receptor 4 (TLR4)/nuclear factor-κB (NF-κB) pathway has been implicated as a key mediator in the pathogenesis of ulcerative colitis (UC); therefore, it has become an attractive target for the treatment of UC. Qing Hua Chang Yin (QHCY) is a traditional Chinese formula, which has been used for many years to clinically treat conditions associated with inflammatory bowel diseases, such as UC. However, the precise mechanisms behind its anti-inflammatory effects remain largely unknown. In this study, using the dextran sulfate sodium (DSS)-induced colitis mouse model, we evaluated the therapeutic effects of QHCY against UC and elucidated the possible underlying molecular mechanisms. We found that the administration of QHCY profoundly ameliorated DSS-induced clinical manifestations, colon shortening and histological damage in the mice with colitis. In addition, treatment with QHCY significantly decreased the DSS-induced secretion of serum amylase. Moreover, QHCY significantly inhibited the DSS-induced expression of TLR4 and myeloid differentiation primary response gene 88 (MyD88), the phosphorylation of IκB and the nuclear translocation of NF-κB. Taken together, our findings suggest that the suppression of the TLR4/NF-κB signaling pathway may be one of the mechanisms involved in the therapeutic effects of QHCY against UC.

更新日期：2019-11-01

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