当前位置: X-MOL 学术FEMS Microbiol. Rev. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Structural diversity in Salmonella O antigens and its genetic basis.
FEMS Microbiology Reviews ( IF 11.3 ) Pub Date : 2013-07-16 , DOI: 10.1111/1574-6976.12034
Bin Liu 1 , Yuriy A Knirel , Lu Feng , Andrei V Perepelov , Sof'ya N Senchenkova , Peter R Reeves , Lei Wang
Affiliation  

This review covers the structures and genetics of the 46 O antigens of Salmonella, a major pathogen of humans and domestic animals. The variation in structures underpins the serological specificity of the 46 recognized serogroups. The O antigen is important for the full function and virulence of many bacteria, and the considerable diversity of O antigens can confer selective advantage. Salmonella O antigens can be divided into two major groups: those which have N-acetylglucosamine (GlcNAc) or N-acetylgalactosamine (GalNAc) and those which have galactose (Gal) as the first sugar in the O unit. In recent years, we have determined 21 chemical structures and sequenced 28 gene clusters for GlcNAc-/GalNAc-initiated O antigens, thus completing the structure and DNA sequence data for the 46 Salmonella O antigens. The structures and gene clusters of the GlcNAc-/GalNAc-initiated O antigens were found to be highly diverse, and 24 of them were found to be identical or closely related to Escherichia coli O antigens. Sequence comparisons indicate that all or most of the shared gene clusters were probably present in the common ancestor, although alternative explanations are also possible. In contrast, the better-known eight Gal-initiated O antigens are closely related both in structures and gene cluster sequences.

中文翻译:

沙门氏菌O抗原的结构多样性及其遗传基础。

这篇综述涵盖了沙门氏菌的46 O抗原的结构和遗传学,沙门氏菌是人类和家畜的主要病原体。结构的变化为46个公认的血清群的血清学特异性奠定了基础。O抗原对于许多细菌的完整功能和毒力很重要,O抗原的相当多的多样性可以赋予其选择优势。沙门氏菌O抗原可分为两大类:具有N-乙酰氨基葡萄糖(GlcNAc)或N-乙酰半乳糖胺(GalNAc)的抗原和具有半乳糖(Gal)作为O单元中第一个糖的抗原。近年来,我们已经确定了GlcNAc / GalNAc引发的O抗原的21种化学结构并测序了28个基因簇,从而完成了46株沙门氏菌O抗原的结构和DNA序列数据。发现由GlcNAc / GalNAc引发的O抗原的结构和基因簇高度多样,其中24个与大肠杆菌O抗原相同或紧密相关。序列比较表明,所有或大多数共享基因簇可能存在于共同祖先中,尽管其他解释也是可能的。相比之下,最著名的八种由Gal启动的O抗原在结构和基因簇序列上都紧密相关。
更新日期:2019-11-01
down
wechat
bug