Systemic lupus erythematosus (SLE) is an autoimmune disease of multifactorial pathoaetiology. Different organs and blood vessels may be affected by chronic inflammation. A direct cause of the disease has not yet been found, so research is being carried out to this effect. The role of the recently identified helper T lymphocyte CD4+, described as Th17, and its dependent cytokines have been of particular interest. The aim of the study was to evaluate IL-17A, IL-17B, IL-17F and IL-23 in 60 SLE patients and 26 age-matched, healthy volunteers and also to investigate the correlation between levels of the investigated cytokines and VEGF, PIGF, as well as number of endothelial cells. IL-17A, IL-17B, IL-17BR and IL-17F levels were found to be higher in SLE patients than in the control group. However, only IL-17F levels showed a statistically significant correlation with the number of endothelial cells (aCEC) and disease activity. Correlations between levels of IL-17F and VEGF and PIGF as well as VEGF and IL-17A and IL-23 were statistically significant. Increased levels of the selected cytokines from the IL-17 family in SLE patients suggest a role for them not only in the inflammatory process but also in angiogenesis. This also highlights the role of IL-17F in activating vascular endothelial cells and consequently blood vessel formation, and in the relationship between the inflammatory reaction and angiogenesis in the development of SLE.

中文翻译：

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系统性红斑狼疮患者白介素（IL）-17A，IL-17B和IL-17F的浓度与内皮细胞和促血管生成细胞因子之间的相关性。

系统性红斑狼疮（SLE）是一种多因素病理学的自身免疫性疾病。慢性炎症可能会影响不同的器官和血管。尚未找到引起该疾病的直接原因，因此正在对此效果进行研究。最近被鉴定为Th17的辅助性T淋巴细胞CD4 +及其依赖的细胞因子的作用引起了人们的特别关注。这项研究的目的是评估60例SLE患者和26位年龄相匹配的健康志愿者中的IL-17A，IL-17B，IL-17F和IL-23，并研究所调查的细胞因子和VEGF水平之间的相关性， PIGF，以及内皮细胞的数量。发现SLE患者的IL-17A，IL-17B，IL-17BR和IL-17F水平高于对照组。然而，只有IL-17F的水平与内皮细胞（aCEC）的数量和疾病活性具有统计学意义的相关性。IL-17F和VEGF和PIGF的水平以及VEGF和IL-17A和IL-23的水平之间的相关性具有统计学意义。在SLE患者中，来自IL-17家族的所选细胞因子水平升高，表明它们不仅在炎症过程中而且在血管生成中都起作用。这也突出了IL-17F在激活血管内皮细胞并因此形成血管中的作用，以及在SLE发展过程中炎症反应与血管生成之间的关系。在SLE患者中，来自IL-17家族的所选细胞因子水平升高，表明它们不仅在炎症过程中而且在血管生成中都起作用。这也突出了IL-17F在激活血管内皮细胞并因此形成血管中的作用，以及在SLE发展过程中炎症反应与血管生成之间的关系。在SLE患者中，来自IL-17家族的所选细胞因子水平升高，表明它们不仅在炎症过程中而且在血管生成中都起作用。这也突出了IL-17F在激活血管内皮细胞并因此形成血管中的作用，以及在SLE发展过程中炎症反应与血管生成之间的关系。