B cells regulate immune responses during infectious, inflammatory and autoimmune diseases. Beside their unique and characteristic antibody production, B lymphocytes can modulate physiological and pathological processes by presenting antigens or synthesizing signaling molecules. In human and mouse diseases, immuno-intervention, targeting B cells, has revealed and highlighted their antibody-independent regulatory contribution. In this review, we focus on B cell-cytokine production, which is commonly disturbed in inflammatory disorders, and describe the B cell cytokine profile in different diseases. Finally, we discuss some key issues for future B cell-targeted therapies.

中文翻译：

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疾病中来自B细胞的细胞因子。

B细胞在传染性，炎性和自身免疫性疾病中调节免疫反应。除了产生独特和特征性的抗体外，B淋巴细胞还可以通过呈递抗原或合成信号分子来调节生理和病理过程。在人类和小鼠疾病中，针对B细胞的免疫干预已揭示并突显了其与抗体无关的调节作用。在这篇综述中，我们着重于在炎症性疾病中通常受到干扰的B细胞细胞因子的产生，并描述了不同疾病中B细胞细胞因子的概况。最后，我们讨论了未来针对B细胞的疗法的一些关键问题。