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Influence of the metabolic control on latency values of visual evoked potentials (VEP) in patients with diabetes mellitus type 1.
Archives Italiennes De Biologie ( IF 1 ) Pub Date : 2013-3-13 , DOI: 10.4449/aib.v150i4.1400
Dragana Matanovic 1 , Srdjan Popovic , Biljana Parapid , Ivana Petronic , Dragana Cirovic , Dejan Nikolic
Affiliation  

The aim of our study was to investigate the relationship between the metabolic control parameters of diabetes mellitus (glycemia and HbA1c) and visual evoked potentials (VEP) latency values. The study included 61 patients with diabetes mellitus type 1 that were hospitalized at the Clinic for Endocrinology, Diabetes and Metabolic Diseases due to the poor metabolic control. All patients were divided into 3 groups. Group 1 consisted of patients on conventional insulin therapy (CT); Group 2 included patients on CT at the moment of hospitalization, with a change towards intensified insulin therapy (IIT); and Group 3 consisted of patients on IIT. Patients with diabetic retinopathy (DR) were excluded from the study. Metabolic control (glycemia and HbA1c) and VEP parameters were compared at the beginning of the study and six months later. After six months of strict glycoregulation, significant improvement in VEP parameters was followed by significant improvement of evaluated parameters of metabolic control. We found statistically significant reduction in frequency of pathological VEP findings, prolonged P100 latency and low amplitude potentials in Group 2, while in Groups 1 and 3 we found that these parameters did not significantly changed but the frequencies were lower. The VEP testing is a noninvasive diagnostic procedure which may help in early diagnosis of DR, prognosis during the metabolic control and treatment. If changes in the retina could be detected before DR is noticed using this noninvasive diagnostic procedure and include patients in a strict glycoregulation, we could be in the position to prevent serious complications that may cause blindness.

中文翻译:

代谢控制对1型糖尿病患者视觉诱发电位(VEP)潜伏期值的影响

我们研究的目的是研究糖尿病的代谢控制参数(血糖和HbA1c)与视觉诱发电位(VEP)潜伏值之间的关系。该研究纳入了61名1型糖尿病患者,他们由于代谢控制不佳而在内分泌,糖尿病和代谢疾病诊所住院。所有患者分为3组。第1组由接受常规胰岛素治疗的患者组成。第2组包括住院时接受CT扫描的患者,并向强化胰岛素治疗(IIT)转变;第3组由IIT患者组成。糖尿病视网膜病变(DR)患者被排除在研究之外。在研究开始时和六个月后比较了代谢控制(血糖和HbA1c)和VEP参数。在严格的糖调节六个月后,VEP参数显着改善,随后代谢控制评估参数显着改善。我们发现,在第2组中,病理性VEP发现的频率,延长的P100潜伏期和低振幅电位在统计学上显着降低,而在第1和第3组中,我们发现这些参数没有显着变化,但频率较低。VEP测试是一种非侵入性诊断程序,可以帮助DR的早期诊断,代谢控制和治疗期间的预后。如果使用这种非侵入性诊断程序在发现DR之前就可以检测到视网膜变化,并且包括严格的糖调节患者,那么我们可以预防可能导致失明的严重并发症。
更新日期:2020-08-21
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