Patient age can impact selection of the optimal antiepileptic drug for a number of reasons. Changes in brain physiology from neonate to elderly, as well as changes in underlying etiologies of epilepsy, could potentially affect the ability of different drugs to control seizures. Unfortunately, much of this is speculative, as good studies demonstrating differences in efficacy across age ranges do not exist. Beyond the issue of efficacy, certain drugs may be more or less appropriate at different ages because of differing pharmacokinetics, including changes in hepatic metabolism, absorption, and elimination. Lack of appropriate drug formulations (such as liquid forms) may be a barrier to using drugs in the very young. Finally, some serious adverse events are seen either exclusively or preferentially at different ages.

中文翻译：

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不同年龄段的 AED 治疗：随着我们大脑的变化，我们的药物选择是否也应该如此？

出于多种原因，患者年龄会影响最佳抗癫痫药物的选择。从新生儿到老年人脑生理的变化，以及癫痫潜在病因的变化，可能会影响不同药物控制癫痫发作的能力。不幸的是，其中大部分是推测性的，因为不存在证明不同年龄范围功效差异的良好研究。除了疗效问题之外，由于药代动力学不同，包括肝脏代谢、吸收和消除的变化，某些药物可能或多或少适用于不同年龄。缺乏适当的药物配方（例如液体形式）可能是在非常年轻的时候使用药物的障碍。最后，一些严重的不良事件在不同年龄只出现或优先出现。