Extremely thermophilic microorganisms have been sources of thermostable and thermoactive enzymes for over 30 years. However, information and insights gained from genome sequences, in conjunction with new tools for molecular genetics, have opened up exciting new possibilities for biotechnological opportunities based on extreme thermophiles that go beyond single-step biotransformations. Although the pace for discovering novel microorganisms has slowed over the past two decades, genome sequence data have provided clues to novel biomolecules and metabolic pathways, which can be mined for a range of new applications. Furthermore, recent advances in molecular genetics for extreme thermophiles have made metabolic engineering for high temperature applications a reality.

中文翻译：

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极端嗜热菌：超越单酶生物催化。

30 多年来，极端嗜热微生物一直是热稳定和热活性酶的来源。然而，从基因组序列中获得的信息和见解，结合分子遗传学的新工具，为基于超越单步生物转化的极端嗜热菌的生物技术机会开辟了令人兴奋的新可能性。尽管在过去的二十年中发现新微生物的步伐有所放缓，但基因组序列数据为新的生物分子和代谢途径提供了线索，可以挖掘这些线索以用于一系列新的应用。此外，极端嗜热菌分子遗传学的最新进展使高温应用的代谢工程成为现实。