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Impulse control disorders in Parkinson's disease: crossroads between neurology, psychiatry and neuroscience.
Behavioural Neurology ( IF 2.8 ) Pub Date : 2013 , DOI: 10.3233/ben-129019
Paulo Bugalho 1 , Albino J Oliveira-Maia
Affiliation  

Non-motor symptoms contribute significantly to Parkinson’s disease (PD) related disability. Impulse control disorders (ICDs) have been recently added to the behavioural spectrum of PD-related non-motor symptoms. Such behaviours are characterized by an inappropriate drive to conduct repetitive behaviours that are usually socially inadequate or result in harmful consequences. Parkinson disease impulse control disorders (PD-ICDs) have raised significant interest in the scientific and medical community, not only because of their incapacitating nature, but also because they may represent a valid model of ICDs beyond PD and a means to study the physiology of drive, impulse control and compulsive actions in the normal brain. In this review, we discuss some unresolved issues regarding PD-ICDs, including the association with psychiatric co-morbidities such as obsessive-compulsive disorder and with dopamine related side effects, such as hallucinations and dyskinesias; the relationship with executive cognitive dysfunction; and the neural underpinnings of ICDs in PD. We also discuss the contribution of neuroscience studies based on animal-models towards a mechanistic explanation of the development of PD-ICDs, specifically regarding corticostriatal control of goal directed and habitual actions.

中文翻译:

帕金森病的冲动控制障碍:神经病学、精神病学和神经科学之间的十字路口。

非运动症状显着导致帕金森病 (PD) 相关的残疾。冲动控制障碍 (ICD) 最近已被添加到 PD 相关非运动症状的行为谱中。此类行为的特点是不适当的驱动力去进行重复性的行为,这些行为通常在社交上是不充分的或会导致有害的后果。帕金森病冲动控制障碍 (PD-ICD) 引起了科学界和医学界的极大兴趣,这不仅是因为它们的无行为能力,还因为它们可能代表了超越 PD 的有效 ICD 模型和研究其生理学的一种手段。正常大脑中的驱动力、冲动控制和强迫行为。在这篇综述中,我们讨论了一些关于 PD-ICD 的未解决问题,包括与精神共病(如强迫症)和多巴胺相关副作用(如幻觉和运动障碍)的关联;与执行认知功能障碍的关系;以及 PD 中 ICD 的神经基础。我们还讨论了基于动物模型的神经科学研究对 PD-ICD 发展的机械解释的贡献,特别是关于目标定向和习惯性动作的皮质纹状体控制。
更新日期:2020-09-25
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