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Adiposity, muscle mass, and muscle strength in relation to functional decline in older persons.
Epidemiologic Reviews ( IF 5.5 ) Pub Date : 2012-12-12 , DOI: 10.1093/epirev/mxs006
Laura A. Schaap , Annemarie Koster , Marjolein Visser

Aging is associated with changes in body composition and muscle strength. This review aimed to determine the relation between different body composition measures and muscle strength measures and functional decline in older men and women. By use of relevant databases (PubMed, Embase, and CINAHL) and keywords in a search from 1976 to April 2012, 50 articles were reviewed that met the inclusion criteria (written in English, a prospective, longitudinal design, involving older persons aged 65 years or more, and at least one of the measures that follow: body mass index (BMI), waist circumference, waist/hip ratio, midarm circumference, fat mass, muscle fat infiltration, muscle mass, or strength as independent variables and a measure of functional decline as outcome measure). Meta-analyses were performed and revealed that BMI ≥30 and low muscle strength were associated with functional decline (pooled odds ratio (OR) = 1.60, 95% confidence interval (CI): 1.43, 1.80, for BMI ≥30 and OR = 1.86, 95% CI: 1.32, 2.64, for muscle strength). Low muscle mass was not significantly associated with functional decline (pooled OR = 1.19, 95% CI: 0.98, 1.45). Future intervention research should focus on positive changes in body composition to prevent onset or worsening of functional decline in old age.

中文翻译:

与老年人功能衰退相关的肥胖,肌肉质量和肌肉力量。

衰老与身体成分和肌肉力量的变化有关。这篇综述旨在确定老年男性和女性的不同身体成分指标和肌肉力量指标与功能下降之间的关系。1976年至2012年4月,通过使用相关数据库(PubMed,Embase和CINAHL)和关键字进行搜索,审查了50篇符合纳入标准的文章(以英语撰写,这是一种前瞻性的纵向设计,涉及65岁的老年人或更多,以及以下至少一项测量:作为独立变量的身体质量指数(BMI),腰围,腰围/臀围比例,中臂围,脂肪质量,肌肉脂肪浸润,肌肉质量或强度,以及功能下降作为结果指标)。进行荟萃分析,发现BMI≥30和低肌力量与功能下降相关(合并比值比(OR)= 1.60,95%置信区间(CI):1.43,1.80,对于BMI≥30和OR = 1.86) ,95%CI:1.32、2.64(用于肌肉力量)。低肌肉质量与功能下降无明显关联(合并OR = 1.19,95%CI:0.98,1.45)。未来的干预研究应侧重于身体成分的积极变化,以防止老年人功能下降的发作或恶化。
更新日期:2019-11-01
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