In this manuscript, we review the latest advancement of microfluidics in molecular imaging probe development. Due to increasing needs for medical imaging, high demand for many types of molecular imaging probes will have to be met by exploiting novel chemistry/radiochemistry and engineering technologies to improve the production and development of suitable probes. The microfluidicbased probe synthesis is currently attracting a great deal of interest because of their potential to deliver many advantages over conventional systems. Numerous chemical reactions have been successfully performed in micro-reactors and the results convincingly demonstrate with great benefits to aid synthetic procedures, such as purer products, higher yields, shorter reaction times compared to the corresponding batch/macroscale reactions, and more benign reaction conditions. Several ‘proof-of-principle’ examples of molecular imaging probe syntheses using microfluidics, along with basics of device architecture and operation, and their potential limitations are discussed here.

在这份手稿中，我们回顾了微流体在分子成像探针开发中的最新进展。由于对医学成像的需求不断增加，必须通过利用新型化学/放射化学和工程技术来改进合适探针的生产和开发来满足对多种类型的分子成像探针的高需求。基于微流体的探针合成目前引起了极大的兴趣，因为它们比传统系统具有许多优势。许多化学反应已在微型反应器中成功进行，结果令人信服地证明了有助于合成程序的巨大好处，例如与相应的批量/大规模反应相比，产品更纯、产率更高、反应时间更短，以及反应条件更温和。