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Mechanics of cell growth
Mechanics Research Communications ( IF 2.4 ) Pub Date : 2012-06-01 , DOI: 10.1016/j.mechrescom.2012.01.010
Gerard A Ateshian 1 , Barclay Morrison , Jeffrey W Holmes , Clark T Hung
Affiliation  

Cell growth describes an essential feature of biological tissues. This growth process may be modeled by using a set of relatively simple governing equations based on the axioms of mass and momentum balance, and using a continuum framework that describes cells and tissues as mixtures of a solid matrix, a solvent and multiple solutes. In this model the mechanics of cell growth is driven by osmotic effects, regulated by the cells' active uptake of solutes and passive uptake of solvent. By accounting for the anisotropy of the cells' cytoskeletal structures or extracellular matrix, as well as external constraints, a wide variety of growing shapes may be produced as illustrated in various examples.

中文翻译:

细胞生长机制

细胞生长描述了生物组织的一个基本特征。这种生长过程可以通过使用一组基于质量和动量平衡公理的相对简单的控制方程来建模,并使用连续框架将细胞和组织描述为固体基质、溶剂和多种溶质的混合物。在这个模型中,细胞生长的机制是由渗透效应驱动的,由细胞主动吸收溶质和被动吸收溶剂来调节。通过考虑细胞的细胞骨架结构或细胞外基质的各向异性以及外部约束,可以产生多种生长形状,如各种示例中所示。
更新日期:2012-06-01
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