N-Alkyltheobromine (1–9) derivatives were obtained by reacting theobromine with appropriate alkyl halide under microwave irradiation at 100–150 W and by conventional synthesis. Formation of by-products of oxygen atom alkylation and 1-N-alkyltheobromine ring opening were considered. The presented compounds 1–5 have been studied as ion carriers in ion-selective membrane electrodes. Selectivity of these membranes was studied towards various anions in addition to transition and heavy metal cations.Graphical AbstractAlkylations of theobromine under microwave irradiation at 100–150 W and by conventional synthesis were performed. Formation of by-products of oxygen atom alkylation and 1-N-alkyltheobromine ring opening were observed. The achieved compounds have been studied as ion carriers in ion-selective membrane electrodes.

中文翻译：

---

抑制由微波辐射刺激的 N-烷基可可碱合成中的杂质形成。膜电极的阳离子和阴离子响应

N-烷基可可碱 (1-9) 衍生物是通过可可碱与适当的烷基卤在 100-150 W 的微波辐射下通过常规合成反应获得的。考虑了氧原子烷基化和1-N-烷基可可碱开环副产物的形成。已经研究了所提出的化合物 1-5 作为离子选择性膜电极中的离子载体。除了过渡金属阳离子和重金属阳离子外，还研究了这些膜对各种阴离子的选择性。图形摘要 在 100-150 W 的微波辐射下和通过常规合成进行了可可碱的烷基化。观察到氧原子烷基化和1-N-烷基可可碱开环副产物的形成。已对所获得的化合物作为离子选择性膜电极中的离子载体进行了研究。