Osteogenesis and angiogenesis are two closely correlated processes during bone growth, development, remodelling and repair.Vascular endothelial growth factor (VEGF) is an essential mediator during the process of angiogenesis. Based on an extensive literature search, which was carried out using the PubMed database and the keywords of osteogenesis, VEGF, endochondral ossification and intramembranous ossification, this manuscript reviews the role of VEGF in ossification, with emphasis on its effect in endochondral and intramembranous ossification. Osteogenesis and angiogenesis are closely correlated processes. VEGF acts as an essential mediator during these processes. It not only functions in bone angiogenesis but also in various aspects of bone development.

中文翻译：

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血管内皮生长因子在骨化中的作用。

成骨和血管生成是骨骼生长、发育、重塑和修复过程中两个密切相关的过程。血管内皮生长因子(VEGF)是血管生成过程中必不可少的介质。基于使用 PubMed 数据库和成骨、VEGF、软骨内骨化和膜内骨化等关键词进行的广泛文献搜索，本手稿回顾了 VEGF 在骨化中的作用，重点是其在软骨内和膜内骨化中的作用。成骨和血管生成是密切相关的过程。VEGF 在这些过程中充当必需的介质。它不仅在骨血管生成中起作用，而且在骨发育的各个方面起作用。