Objectives: To investigate the principal psychopathological dimensions of post-stroke depression (PSD) through the assessment of the factorial structure of the Post-Stroke Depression Rating Scale (PSDRS).Methods: We enrolled ninety-eight subjects with PSD, who underwent the PSDRS, MMSE and Barthel Index. Information about demographic, clinical, and neuroanatomical factors was collected.Results: The factor analysis extracted three factors accounting for 63.4% of the total variance, and identified as: (1) “Depressive and Anxious Symptoms“ (DAS); (2) “Lack of Emotional Control” (LEC); 3) “Reduced Motivation” (RM). On multivariate statistics, DAS severity was predicted by previous history of mood disorders and Barthel Index; LEC severity was predicted by Barthel Index; RM severity was predicted by age.Conclusions: The PSDRS displayed a reliable factor structure that agreed with previous interpretation of PSD. In particular, core depressive symptoms seem to be related to premorbid personality and functional status, whereas apathy/anhedonia may be connected to brain aging.

中文翻译：

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中风后抑郁症：主要的现象学集群及其与临床措施的关系。

目的：通过评估卒中后抑郁量表 (PSDRS) 的因子结构，研究卒中后抑郁 (PSD) 的主要精神病理学维度。方法：我们招募了 98 名 PSD 受试者，他们接受了 PSDRS、MMSE 和 Barthel 指数。收集了有关人口统计学、临床和神经解剖学因素的信息。结果：因子分析提取了占总方差63.4%的三个因子，确定为：（1）“抑郁和焦虑症状”（DAS）；（2）“缺乏情绪控制”（LEC）；3）“降低动机”（RM）。在多变量统计中，DAS 的严重程度是由既往的情绪障碍病史和 Barthel 指数预测的；LEC 严重程度由 Barthel 指数预测；RM 严重程度由年龄预测。结论： PSDRS 显示了一个可靠的因子结构，与先前对 PSD 的解释一致。特别是，核心抑郁症状似乎与病前人格和功能状态有关，而冷漠/快感缺乏可能与大脑老化有关。