Atherosclerosis as a main etiopathogenetic source for coronary artery disease (CAD) development is intimately related to dynamic changes in the extracellular matrix (ECM). Elevated levels of MMP-13 have been observed in human atherosclerotic plaques which could also involve variability in MMP-13 gene. The aim of the study was to associate rs640198 polymorphism with CAD and/or with its severity.The study comprised 1071 consecutive patients with suspected or known coronary artery disease (CAD), confirmed by coronary angiography.Genotyping for the rs640198 polymorphism in MMP-13 gene was performed using Taqman® assay. The TT and TG genotypes of rs640198 polymorphism in MMP-13 gene confer the significantly increased risk of triple vessel disease compared to patients without atherosclerotic lesions in coronary arteries (odds ratio = 1.64, Pcorr = 0.05). Furthermore, an increased risk of having 5 and more stenoses (odds ratio = 1.90, Pcorr = 0.004) was observed in TT and TG carriers (sensitivity of 0.613 and a specificity of 0.544; power of the test is 0.87).The T allele of MMP-13 intron polymorphism rs640198 is associated with the severity of coronary artery disease, represented by the number of affected arteries as well as by the number of stenoses confirmed by coronarography.

中文翻译：

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rs640198 多态性中的基质金属蛋白酶 13 基因型与严重的冠状动脉疾病有关。

动脉粥样硬化作为冠状动脉疾病 (CAD) 发展的主要病因与细胞外基质 (ECM) 的动态变化密切相关。在人类动脉粥样硬化斑块中观察到 MMP-13 水平升高，这也可能涉及 MMP-13 基因的变异。该研究的目的是将 rs640198 多态性与 CAD 和/或其严重程度相关联。该研究包括 1071 名疑似或已知冠状动脉疾病 (CAD) 的连续患者，经冠状动脉造影证实。 MMP-13 中 rs640198 多态性的基因分型基因使用 Taqman® 测定进行。与没有冠状动脉粥样硬化病变的患者相比，MMP-13 基因中 rs640198 多态性的 TT 和 TG 基因型使三支血管疾病的风险显着增加（优势比 = 1.64，Pcorr = 0.05）。