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Improved Detection Sensitivity of Line-Scanning Optical Coherence Microscopy
IEEE Journal of Selected Topics in Quantum Electronics ( IF 4.9 ) Pub Date : 2012-05-01 , DOI: 10.1109/jstqe.2011.2161758
Yu Chen 1 , Shu-Wei Huang , Chao Zhou , Benjamin Potsaid , James G Fujimoto
Affiliation  

Optical coherence microscopy (OCM) is a promising technology for high-resolution cellular-level imaging in human tissues. Line-scanning OCM is a new form of OCM that utilizes line-field illumination for parallel detection. In this study, we demonstrate improved detection sensitivity by using an achromatic design for line-field generation. This system operates at 830-nm wavelength with 82-nm bandwidth. The measured axial resolution is 3.9 μm in air (corresponding to ~2.9 μm in tissue), and the transverse resolutions are 2.1 μm along the line-field illumination direction and 1.7 μm perpendicular to line illumination direction. The measured sensitivity is 98 dB with 25 line averages, resulting in an imaging speed of ~2 frames/s (516 lines/s). Real-time, cellular-level imaging of scattering tissues is demonstrated using human-colon specimens.

中文翻译:

提高线扫描光学相干显微镜的检测灵敏度

光学相干显微镜 (OCM) 是一种很有前途的技术,可用于人体组织中的高分辨率细胞级成像。线扫描 OCM 是一种新形式的 OCM,它利用线场照明进行并行检测。在这项研究中,我们通过使用消色差设计来生成线场,证明了检测灵敏度的提高。该系统在 830 纳米波长和 82 纳米带宽下运行。测量的轴向分辨率在空气中为 3.9 μm(对应于组织中的 ~2.9 μm),横向分辨率沿线场照明方向为 2.1 μm,垂直于线照明方向为 1.7 μm。测得的灵敏度为 98 dB,具有 25 条线平均值,成像速度约为 2 帧/秒(516 线/秒)。散射组织的实时、细胞水平成像使用人体结肠标本进行演示。
更新日期:2012-05-01
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