Tumor hypoxia is a negative prognostic factor and its precise imaging is of great relevance to therapy planning. The present review summarizes various strategies of probe design for imaging hypoxia with a variety of techniques such as PET, SPECT and fluorescence imaging. Synthesis of some important probes that are used for preclinical and clinical imaging and their mechanism of binding in hypoxia are also discussed.

中文翻译：

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缺氧的分子成像：探针设计和应用的策略。

肿瘤缺氧是一个不利的预后因素，其精确成像与治疗计划密切相关。本综述总结了使用各种技术（如 PET、SPECT 和荧光成像）对缺氧成像进行探针设计的各种策略。还讨论了一些用于临床前和临床成像的重要探针的合成及其在缺氧条件下的结合机制。