Hypocretin (Hcrt) has been implicated in the control of motor activity and in respiration and cardiovascular changes. Loss of Hcrt in narcolepsy is linked to sleepiness and to cataplexy, a sudden loss of muscle tone which is triggered by sudden strong emotions. In the current study we have compared the effects of treadmill running, to yard play on cerebrospinal fluid (CSF) Hcrt level in normal dogs. We find that treadmill locomotion, at a wide range of speeds, does not increase Hcrt level beyond baseline, whereas yard play produces a substantial increase in Hcrt, even though both activities produce comparable increases in heart rate, respiration and body temperature. We conclude that motor and cardiovascular changes are not sufficient to elevate CSF levels of Hcrt and we hypothesize that the emotional aspects of yard play account for the observed increase in Hcrt.

中文翻译：

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脑脊液下丘脑分泌素（食欲素）水平会因玩耍而升高，但不会因运动及其相关的心率、血压、呼吸或体温变化而升高。

Hypocretin (Hcrt) 与运动活动的控制以及呼吸和心血管变化有关。发作性睡病中 Hcrt 的丧失与嗜睡和猝倒有关，猝倒是一种由突然强烈的情绪引发的肌肉张力突然丧失。在目前的研究中，我们比较了跑步机跑步和院子里玩耍对正常狗脑脊液 (CSF) Hcrt 水平的影响。我们发现跑步机运动在很宽的速度范围内不会将 Hcrt 水平提高到基线以上，而在院子里玩耍会导致 Hcrt 显着增加，即使这两种活动都会使心率、呼吸和体温产生相当的增加。