New generation sequencing systems are changing how molecular biology is practiced. The widely promoted $1000 genome will be a reality with attendant changes for healthcare, including personalized medicine. More broadly the genomes of many new organisms with large samplings from populations will be commonplace. What is less appreciated is the explosive demands on computation, both for CPU cycles and storage as well as the need for new computational methods. In this article we will survey some of these developments and demands.

中文翻译：

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新一代：测序机及其计算挑战

新一代测序系统正在改变分子生物学的实践方式。广泛宣传的 1000 美元基因组将成为现实，伴随着医疗保健的变化，包括个性化医疗。更广泛地说，从人群中大量采样的许多新生物的基因组将是司空见惯的。不太受欢迎的是对计算的爆炸性需求，包括 CPU 周期和存储以及对新计算方法的需求。在本文中，我们将调查其中的一些发展和需求。