当前位置: X-MOL 学术J. Am. Water Works Assoc. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Cancer risk assessment: importance of identifying mechanisms of action.
Journal American Water Works Association ( IF 0.7 ) Pub Date : 1990-10-01
R J Bull 1
Affiliation  

The process by which regulatory standards are established for drinking water contaminants is based on extrapolating animal toxicity data to humans using a standard mathematical model. The assumptions and judgments involved introduce a relatively high degree of uncertainty and conservativeness into both the qualitative and quantitative aspects of the process. Setting standards based on knowledge of specific mechanisms of carcinogenicity would decrease the uncertainty involved in risk assessment. Understanding these mechanisms is necessary for arriving at the most appropriate mathematical construct for calculating more rational standards.

中文翻译:

癌症风险评估:确定作用机制的重要性。

建立饮用水污染物监管标准的过程是基于使用标准数学模型将动物毒性数据外推给人类的结果。涉及的假设和判断在过程的定性和定量方面都引入了相对较高的不确定性和保守性。根据对特定致癌机制的了解制定标准将减少风险评估中的不确定性。了解这些机制对于获得用于计算更合理标准的最合适的数学构造是必要的。
更新日期:2019-11-01
down
wechat
bug