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Impact of functional inorganic nanotubes f-INTs-WS2 on hemolysis, platelet function and coagulation.
Nano Convergence ( IF 11.7 ) Pub Date : 2018-10-30 , DOI: 10.1186/s40580-018-0162-1 Julie Laloy 1, 2 , Hélène Haguet 2, 3 , Lutfiye Alpan 1, 2 , Daniel Raichman 4 , Jean-Michel Dogné 1, 2 , Jean-Paul Lellouche 4
Nano Convergence ( IF 11.7 ) Pub Date : 2018-10-30 , DOI: 10.1186/s40580-018-0162-1 Julie Laloy 1, 2 , Hélène Haguet 2, 3 , Lutfiye Alpan 1, 2 , Daniel Raichman 4 , Jean-Michel Dogné 1, 2 , Jean-Paul Lellouche 4
Affiliation
Inorganic transition metal dichalcogenide nanostructures are interesting for several biomedical applications such as coating for medical devices (e.g. endodontic files, catheter stents) and reinforcement of scaffolds for tissue engineering. However, their impact on human blood is unknown. A unique nanomaterial surface-engineering chemical methodology was used to fabricate functional polyacidic polyCOOH inorganic nanotubes of tungsten disulfide towards covalent binding of any desired molecule/organic species via chemical activation/reactivity of this former polyCOOH shell. The impact of these nanotubes on hemolysis, platelet aggregation and blood coagulation has been assessed using spectrophotometric measurement, light transmission aggregometry and thrombin generation assays. The functionalized nanotubes do not induce hemolysis but decrease platelet aggregation and induce coagulation through intrinsic pathway activation. The functional nanotubes were found to be more thrombogenic than the non-functional ones, suggesting lower hemocompatibility and increased thrombotic risk with functionalized tungsten disulfide nanotubes. These functionalized nanotubes should be used with caution in blood-contacting devices.
中文翻译:
功能性无机纳米管 f-INTs-WS2 对溶血、血小板功能和凝血的影响。
无机过渡金属二硫属化物纳米结构对于多种生物医学应用很有意义,例如医疗器械涂层(例如牙髓锉、导管支架)和组织工程支架的加固。然而,它们对人体血液的影响尚不清楚。使用独特的纳米材料表面工程化学方法来制造二硫化钨的功能性多元酸聚COOH无机纳米管,通过这种前聚COOH壳的化学活化/反应性来共价结合任何所需的分子/有机物质。使用分光光度测量、光透射聚集测量和凝血酶生成测定来评估这些纳米管对溶血、血小板聚集和血液凝固的影响。功能化纳米管不会引起溶血,但会减少血小板聚集并通过内在途径激活诱导凝血。研究发现,功能性纳米管比非功能性纳米管更容易形成血栓,这表明功能化二硫化钨纳米管的血液相容性较低,血栓形成风险增加。这些功能化纳米管在血液接触装置中应谨慎使用。
更新日期:2018-10-30
中文翻译:
功能性无机纳米管 f-INTs-WS2 对溶血、血小板功能和凝血的影响。
无机过渡金属二硫属化物纳米结构对于多种生物医学应用很有意义,例如医疗器械涂层(例如牙髓锉、导管支架)和组织工程支架的加固。然而,它们对人体血液的影响尚不清楚。使用独特的纳米材料表面工程化学方法来制造二硫化钨的功能性多元酸聚COOH无机纳米管,通过这种前聚COOH壳的化学活化/反应性来共价结合任何所需的分子/有机物质。使用分光光度测量、光透射聚集测量和凝血酶生成测定来评估这些纳米管对溶血、血小板聚集和血液凝固的影响。功能化纳米管不会引起溶血,但会减少血小板聚集并通过内在途径激活诱导凝血。研究发现,功能性纳米管比非功能性纳米管更容易形成血栓,这表明功能化二硫化钨纳米管的血液相容性较低,血栓形成风险增加。这些功能化纳米管在血液接触装置中应谨慎使用。