Carbon Monoxide (CO), at low concentrations, can have a variety of positive effects on the body including anti-apoptosis, anti-inflammatory, anti-oxidative and anti-proliferative effects. Although CO has great potential for use as a potent medical bioactive gas, for it to exist in the body in stable form, it must be associated with a carrier. Hemoglobin (Hb) represents a promising material for use as a CO carrier because most of the total CO in the body is stored associated with Hb in red blood cells (RBC). Attempts have been made to develop an Hb-based CO carrying system using RBC and Hb-based artificial oxygen carriers. Some of these have been reported to be safe and to have therapeutic value as a CO donor in preclinical and clinical studies. In the present review, we overview the potential of RBC and Hb-based artificial oxygen carriers as CO carriers based on the currently available literature evidence for their use in pharmaceutical therapy against intractable disorders.

一氧化碳（CO）含量低，对人体具有多种积极作用，包括抗凋亡，抗炎，抗氧化和抗增殖作用。尽管CO具有强大的潜力用作强大的医用生物活性气体，但要使其以稳定的形式存在于体内，它必须与载体结合。血红蛋白（Hb）代表一种有前途的材料，可用作CO载体，因为体内大部分的总CO与Hb一起储存在红细胞（RBC）中。已经尝试开发使用RBC和基于Hb的人造氧载体的基于Hb的CO携带系统。据报道，其中一些在临床前和临床研究中是安全的，具有作为CO供体的治疗价值。在目前的评论中，