Discrete simulations of genetic regulatory networks were used to study subsystems of yeast successfully. However, implementations of existing models underlying these simulations do not support a graphic interface, and require computations necessary to analyze their results to be done manually. Furthermore, differences between existing models suggest that an enriched model, encompassing both existing models, is needed. We developed a software tool, GRegNetSim, that allows the end-user to describe genetic regulatory networks graphically. The user can specify various transition functions at different nodes of the network, supporting, for example, threshold and gradient effects, and then apply the network to a variety of inputs. GRegNetSim displays the relationship between the inputs and the mode of behavior of the network in a graphic form that is easy to interpret. Furthermore, it can automatically extract statistical data necessary to analyze the simulations. The discrete simulations performed by GRegNetSim can be used to elucidate and predict the behavior, structure and properties of genetic regulatory networks in a unified manner. GRegNetSim is implemented as a Cytoscape App. Installation files, examples and source code, along with a detailed user guide, are freely available at https://sites.google.com/site/gregnetsim/.

中文翻译：

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关于GRegNetSim的说明：遗传监管网络的离散仿真和分析工具。

遗传调控网络的离散模拟被成功地用于研究酵母的子系统。但是，基于这些模拟的现有模型的实现不支持图形界面，并且需要进行分析以手动完成其结果所需的计算。此外，现有模型之间的差异表明需要包含两个现有模型的丰富模型。我们开发了软件工具GRegNetSim，该软件工具允许最终用户以图形方式描述遗传调控网络。用户可以在网络的不同节点上指定各种过渡功能，以支持例如阈值和渐变效果，然后将网络应用于各种输入。GRegNetSim以易于理解的图形形式显示输入和网络行为模式之间的关系。此外，它可以自动提取分析模拟所需的统计数据。由GRegNetSim执行的离散模拟可用于以统一的方式阐明和预测基因调控网络的行为，结构和特性。GRegNetSim被实现为Cytoscape App。可从https://sites.google.com/site/gregnetsim/免费获得安装文件，示例和源代码以及详细的用户指南。遗传调控网络的结构和性质统一。GRegNetSim被实现为Cytoscape应用程序。可从https://sites.google.com/site/gregnetsim/免费获得安装文件，示例和源代码以及详细的用户指南。遗传调控网络的结构和性质统一。GRegNetSim被实现为Cytoscape App。可从https://sites.google.com/site/gregnetsim/免费获得安装文件，示例和源代码以及详细的用户指南。