Obsessive-compulsive disorder (OCD) is a common inheritable psychiatric disorder characteristic of repetitive thinking, imagination (obsession), and stereotyped behaviors (compulsive). To explore whether there is an alteration of brain functional connectivity (BFC) in patients with OCD during rest, electroencephalogram (EEG) data of healthy controls (HCs) and patients with OCD were collected during rest in both eyes-closed and eyes-open states. Synchronization likelihood and graph theory were applied to construct and analyze brain functional networks of patients with OCD and HCs. Patients with OCD showed abnormal graph-theoretic parameters and impaired small world features in the alpha and beta bands. In addition, the topological analysis consistently showed that the long-range BFC of alpha rhythm was significantly reduced in the bilateral posterior areas in patients with OCD in comparison with HCs, while the BFC in the beta rhythm was significantly increased only in the eyes-open state. The findings suggest that the BFC of patients with OCD show abnormal small-world features and altered topological structure during rest, mainly in alpha and beta bands, which may provide a new insight for the diagnosis and treatment of OCD.

中文翻译：

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休息期间强迫症患者阿尔法节律的功能连接改变

强迫症 (OCD) 是一种常见的可遗传的精神障碍，其特征是重复性思维、想象力（痴迷）和刻板行为（强迫症）。为了探讨强迫症患者在休息时是否存在脑功能连接（BFC）的改变，收集了健康对照（HCs）和强迫症患者在闭眼和睁眼状态下休息时的脑电图（EEG）数据. 应用同步似然和图论来构建和分析 OCD 和 HC 患者的脑功能网络。强迫症患者表现出异常的图论参数和 alpha 和 beta 波段的小世界特征受损。此外，拓扑分析一致表明，与 HC 相比，OCD 患者双侧后部区域 α 节律的长程 BFC 显着降低，而 β 节律中的 BFC 仅在睁眼状态下显着增加。研究结果表明，OCD患者的BFC在休息时表现出异常的小世界特征和拓扑结构的改变，主要表现在α和β波段，这可能为OCD的诊断和治疗提供新的思路。