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Impact of fixation, coil, and number of excitations on diffusion tensor imaging of rat brains at 7.0 T.
European Radiology Experimental Pub Date : 2018-10-03 , DOI: 10.1186/s41747-018-0057-2
Chunhua Wang 1 , Li Song 1 , Ruzhi Zhang 1 , Fabao Gao 1
Affiliation  

Background

We sought to compare diffusion tensor imaging (DTI) parameters in vivo and ex vivo in the brain and to explore the effects of radiofrequency coil and number of excitations on ex vivo DTI parameters.

Methods

Six Sprague–Dawley rat brains were used to obtain in vivo and ex vivo DTI maps with different coils and number of excitations. DTI parameters of white matter and grey matter including diffusivities, fractional anisotropy, and other dimensionless ratios (λ2/λ1, λ3/λ1, and λ2/λ3) were obtained from reconstruction maps. Comparisons of ex vivo signal-to-noise ratio with different coils and number of excitations were conducted.

Results

Diffusivities decreased significantly after fixation in all the selected white matter and grey matter regions of interest (all at p < 0.001). The diffusivities in white matter integrity decreased more than in grey matter integrity after fixation (all at p < 0.001). The ratio of λ2/λ3 in the major brain structures changed after fixation (most at p < 0.05). There were differences in major ex vivo brain structures in DTI parameters and signal-to-noise ratio between surface coil and volume coil, and between one and four excitations (most at p < 0.05).

Conclusion

The impact of fixation, coil, and number of excitations on DTI parameters should be taken into consideration in clinical and experimental studies at 7.0 T.


中文翻译:

固定,线圈和激发次数对7.0 T大鼠脑扩散张量成像的影响。

背景

我们试图比较体内离体在大脑中的扩散张量成像(DTI)参数并探讨射频线圈和激发次数对离体DTI参数的影响。

方法

使用六个Sprague-Dawley大鼠大脑来获得具有不同线圈和激发次数的体内离体DTI图。从重建图获得了白质和灰质的DTI参数,包括扩散率,分数各向异性和其他无量纲比(λ2/λ1,λ3/λ1和λ2/λ3)。比较了不同线圈和激发次数的离体信噪比。

结果

固定后,所有选定的感兴趣的白质和灰质区域的扩散率均显着降低(均在p  <0.001)。固色后白质完整性的扩散性比灰质完整性的扩散性降低更多(所有p  <0.001)。固定后,主要脑结构中λ2/λ3的比例发生变化(大多数在p  <0.05)。主要的离体大脑结构在表面线圈和体积线圈之间以及一到四个激发之间的DTI参数和信噪比方面存在差异(大多数为p  <0.05)。

结论

在7.0 T的临床和实验研究中,应考虑固定,线圈和激发次数对DTI参数的影响。
更新日期:2018-10-03
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