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Synthesis, Characterization, and Antimicrobial Activity of Novel Sulfonated Copper-Triazine Complexes.
Bioinorganic Chemistry and Applications ( IF 3.8 ) Pub Date : 2018-08-29 , DOI: 10.1155/2018/2530851
Supun Katugampala 1 , Inoka C Perera 2 , Chandrika Nanayakkara 3 , Theshini Perera 1
Affiliation  

Metallotriazine complexes possess interesting biological and medicinal properties, and the present study focuses on the synthesis, characterization, and antimicrobial activity of four novel copper-triazine derivatives in search of potent antibacterial and antifungal drug leads. In this study, 3-(2-pyridyl)-5,6-diphenyl-1,2,4-triazine-4,4′-disulfonic acid monosodium salt (L1, ferrozine) and 3-(2-pyridyl)-5,6-di(2-furyl)-1,2,4-triazine-5,5′-disulfonic acid disodium salt (L2, ferene) have been used as ligands to study the complexation towards copper(II). The synthesized complexes, [CuCl2(ferrozine)]·7H2O·MeOH (1), [CuCl2(ferrozine)2]·5H2O·MeOH (2), [CuCl2(ferene)]·H2O·MeOH (3), and [CuCl2(ferene)2]·H2O·MeOH (4), have been characterized spectroscopically, and preliminary bioassays have been carried out. FTIR spectroscopic data have shown that N=N and C=N stretching frequencies of complexes have been shifted towards lower frequencies in comparison with that of the ligands, confirming new bond formation between Cu and N, which in turn lowers the strength of N=N and C=N bonds. In addition, a bathochromic shift has been observed for UV-visible spectra of complexes (1), (2), (3), and (4). Furthermore, elemental analysis data have been useful to obtain empirical formulas of these complexes and to establish the purity of each complex. Complexes (1) and (2) have shown antibacterial activity for both S. aureus (ATCC® 25923) and E. coli (ATCC® 25922) at 1 mg/disc concentration, and ferrozine has shown a larger inhibition zone against the clinical sample of C. albicans at 1 mg/disc concentration in comparison with the positive control, fluconazole.

中文翻译:

新型磺化铜-三嗪配合物的合成,表征和抗菌活性。

金属三嗪复合物具有有趣的生物学和药用特性,本研究着重于四种新型三嗪铜三嗪衍生物的合成,表征和抗菌活性,以寻找有效的抗菌和抗真菌药物。在这项研究中,3-(2-吡啶基)-5,6-二苯基-1,2,4-三嗪-4,4'-二磺酸一钠盐(L1,甲硼嗪)和3-(2-吡啶基)-5 1,6-二(2-呋喃基)-1,2,4-三嗪-5,5'-二磺酸二钠盐(L2,,)已被用作配体来研究与铜(II)的络合。合成的配合物[CuCl 2(ferrozine)]·7H 2 O·MeOH(1),[CuCl 2(ferrozine)2 ]·5H 2 O·MeOH(2),[CuCl光谱学上表征了2(Feene)]·H 2 O·MeOH(3)和[CuCl 2(Feene)2 ]·H 2 O·MeOH(4),并进行了初步的生物测定。FTIR光谱数据表明,与配位体相比,配合物的N = N和C = N拉伸频率已移向更低的频率,这证实了Cu和N之间形成了新的键,从而降低了N = N的强度。 C = N键。此外,已观察到配合物(1),(2),(3)和(4)的紫外可见光谱发生红移。)。此外,元素分析数据已用于获得这些配合物的经验公式并确定每种配合物的纯度。配合物(1)和(2)在1 mg / disc的浓度下对金黄色葡萄球菌(ATCC®25923)和大肠杆菌(ATCC®25922 )均显示出抗菌活性,并且铁硼嗪对临床样品显示出更大的抑制区的白色念珠菌以1mg /圆盘浓度在与阳性对照相比,氟康唑。
更新日期:2018-08-29
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