Overall survival for the high-risk group of neuroblastoma (NB) patients still remains at 40-50%, necessitating the establishment of a curable treatment. LIM domain only 1 (LMO1) gene encoding a transcriptional regulator is an NB-susceptibility gene with a tumor-promoting activity. Previously we conducted chromatin immunoprecipitation and DNA sequencing analyses on NB cell lines and identified 3 protein-coding genes regulated by LMO1. In this study, we extended our analyses to capture microRNA genes directly or indirectly regulated by LMO1.

中文翻译：

---

LMO1在神经母细胞瘤中间接抑制肿瘤抑制性let-7家族MicroRNA的表达。

高危组神经母细胞瘤（NB）患者的总生存率仍保持在40％至50％，因此有必要建立一种可治愈的治疗方法。编码转录调节子的仅LIM结构域1（LMO1）基因是具有肿瘤促进活性的NB敏感性基因。以前，我们在NB细胞系上进行了染色质免疫沉淀和DNA测序分析，并鉴定了3个受LMO1调控的蛋白编码基因。在这项研究中，我们扩展了分析范围，以捕获直接或间接受LMO1调控的microRNA基因。