Copy Number Alterations in Tumor Genomes Deleting Antineoplastic Drug Targets Partially Compensated by Complementary Amplifications.,Cancer Genomics & Proteomics

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Copy Number Alterations in Tumor Genomes Deleting Antineoplastic Drug Targets Partially Compensated by Complementary Amplifications.
Cancer Genomics & Proteomics ( IF 2.5 ) Pub Date : 2018-9-9 , DOI: 10.21873/cgp.20095
Ha Vu Tran _{1,

2} , Alexandra K Kiemer ₃ , Volkhard Helms ₄

Affiliation

Genomic DNA copy number alterations (CNAs) are frequent in tumors and have been catalogued by The Cancer Genome Atlas project. Emergence of chemoresistance frequently renders drug therapies ineffective.

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