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An Overview of the Potential Therapeutic Applications of CO-Releasing Molecules.
Bioinorganic Chemistry and Applications ( IF 3.8 ) Pub Date : 2018-08-12 , DOI: 10.1155/2018/8547364
Aiten Ismailova 1 , David Kuter 1 , D Scott Bohle 1 , Ian S Butler 1
Affiliation  

Carbon monoxide (CO) has long been known as the “silent killer” owing to its ability to form carboxyhemoglobin—the main cause of CO poisoning in humans. Its role as an endogenous neurotransmitter, however, was suggested in the early 1990s. Since then, the biological activity of CO has been widely examined via both the direct administration of CO and in the form of so-called “carbon monoxide releasing molecules (CORMs).” This overview will explore the general physiological effects and potential therapeutic applications of CO when delivered in the form of CORMs.

中文翻译:

释放CO分子的潜在治疗应用概述。

一氧化碳(CO)形成碳氧合血红蛋白的能力长期以来一直被称为“沉默杀手”,后者是人类CO中毒的主要原因。然而,在1990年代初期就提出了其作为内源性神经递质的作用。从那时起,通过直接施用CO以及所谓的“一氧化碳释放分子(CORM)”的形式,广泛地检查了CO的生物学活性。本概述将探讨以CORM形式递送时,CO的一般生理效应和潜在的治疗应用。
更新日期:2018-08-12
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