The outflow of the cerebrospinal fluid (CSF) in animals was over the years the subject of detailed analysis. For a long time it was stated that arachnoid granulations of the venous sinuses play a key role in CSF circulation. However, recent studies on this subject have shown that a considerable part of the CSF is drained to the lymphatic vessels. Moreover, disorders in the CSF passage may result in severe central nervous system diseases such as e.g. hydrocephalus. In this paper, we summarize the current knowledge concerning the lymphatic drainage of the CSF in mammals. We present in detail comparative anatomy of different species taking into account cranial and spinal compartment. In addition, we clarified role of the lymphatic vessels in the CSF outflow and the relationship between impairment in this transport and central nervous system diseases. In the author's opinion knowledge on CSF circulation is still poorly examined and therefore required comment.

中文翻译：

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哺乳动物脑脊液的淋巴引流-蛛网膜颗粒是脑脊液流出的主要途径吗？

多年来，动物中脑脊液（CSF）的流出一直是详细分析的主题。长期以来，人们一直认为静脉窦的蛛网膜颗粒在脑脊液循环中起关键作用。但是，有关该主题的最新研究表明，相当一部分的CSF排泄到淋巴管。此外，CSF通道中的疾病可能导致严重的中枢神经系统疾病，例如脑积水。在本文中，我们总结了有关哺乳动物CSF淋巴引流的当前知识。我们详细介绍了考虑到颅骨和脊柱隔室的不同物种的比较解剖。此外，我们阐明了淋巴管在脑脊液流出中的作用以及这种运输障碍与中枢神经系统疾病之间的关系。