Apathy is the most common neuropsychiatric symptom in patients with Alzheimer's disease (AD). The presence of apathy has been related to greater caregiver distress, decreased quality of life, and increased morbidity. Here we review the most recent studies on this neuropsychiatric syndrome, focusing on prevalence, impact on quality of life, behavioural and neuroimaging studies, and treatment options. The results of some investigations on the behavioural and neuroanatomical profile of apathy in AD point to a role of frontostriatal circuits, specifically involving the anterior cingulate cortex. However, small and heterogeneous samples, lack of control for disease severity, and non-specific apathy scales complicate interpretation of results. Future studies might benefit from studying multiple dimensions of apathy within conceptual frameworks which allow for a deconstruction of underlying mechanisms.

冷漠是阿尔茨海默病（AD）患者最常见的神经精神症状。冷漠的存在与护理人员更大的痛苦、生活质量下降和发病率增加有关。在这里，我们回顾了关于这种神经精神综合征的最新研究，重点关注患病率、对生活质量的影响、行为和神经影像学研究以及治疗选择。对 AD 冷漠的行为和神经解剖学特征的一些研究结果指出了额纹状体回路的作用，特别是涉及前扣带皮层。然而，小且异质的样本、缺乏对疾病严重程度的控制以及非特异性冷漠量表使结果的解释变得复杂。未来的研究可能会受益于在概念框架内研究冷漠的多个维度，从而解构潜在的机制。