Diabetes, an unresolved metabolic disorder, and lead contamination are prevalent problems in contemporary society. Previously, we have reported that either diabetes or lead exposure resulted in reproductive toxicity in male Wistar rats. The aim of this study was to evaluate whether diabetic rats exposed to lead demonstrate a higher degree of reproductive toxicity when compared with lead-exposed control rats. Diabetes was induced by injecting a single dose of streptozotocin (50 mg per kg body weight). Control and diabetic rats were exposed to lead at a concentration of 819 mg L-1 (0.15% lead acetate) through drinking water for a period of 30 days and assessed for reproductive and oxidative end points. The relative weights of the testes, epididymis, seminal vesicles, and the prostate gland were significantly decreased in diabetic rats. Daily sperm production, epididymal sperm count, motile, viable and HOS-tail swelled sperms, serum testosterone levels and testicular 3β- and 17β-hydroxysteroid dehydrogenase activity levels were significantly decreased in diabetic rats. Significant reductions in testicular and epididymal antioxidant enzyme activity levels and glutathione levels were observed in diabetic rats with an elevation in the levels of superoxide anions, hydrogen peroxides, and lipid peroxidation. A significant reduction in the number of implantations associated with elevated pre- and post-implantation losses was observed in females mated with diabetic males. Mild histopathological malformations were observed in the testis of the diabetic rats. Similar reproductive and oxidative toxicities were observed in lead-exposed control rats. Furthermore, lead exposed diabetic rats showed additional deterioration in reproductive end points and a noteworthy elevation in oxidative toxicity, suggesting that treatment with lead exacerbates reproductive toxicity in streptozotocin-induced diabetic rats.

中文翻译：

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铅加剧了雄性Wistar大鼠的糖尿病引起的生殖毒性。

糖尿病，一种尚未解决的代谢紊乱以及铅污染是当代社会普遍存在的问题。以前，我们已经报道过糖尿病或铅暴露会导致雄性Wistar大鼠产生生殖毒性。这项研究的目的是评估与暴露于铅的对照大鼠相比，暴露于铅的糖尿病大鼠是否表现出更高程度的生殖毒性。通过注射单剂量的链脲佐菌素（每公斤体重50毫克）来诱发糖尿病。对照组和糖尿病大鼠通过饮用水暴露于浓度为819 mg L-1（0.15％乙酸铅）的铅中，持续30天，并评估其生殖和氧化终点。在糖尿病大鼠中，睾丸，附睾，精囊和前列腺的相对重量显着降低。糖尿病大鼠的每日精子产生量，附睾精子数量，活动性，存活率和HOS-尾部肿胀的精子，血清睾丸激素水平以及睾丸3β-和17β-羟基类固醇脱氢酶活性水平显着降低。在糖尿病大鼠中观察到睾丸和附睾抗氧化酶活性水平和谷胱甘肽水平显着降低，其中超氧化物阴离子，过氧化氢和脂质过氧化水平升高。在与糖尿病男性交配的女性中，观察到与增加的植入前和植入后损失相关的植入数量显着减少。在糖尿病大鼠的睾丸中观察到轻度的组织病理学畸形。在铅暴露的对照大鼠中观察到类似的生殖和氧化毒性。此外，