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Salvianolic acid B protects against doxorubicin induced cardiac dysfunction via inhibition of ER stress mediated cardiomyocyte apoptosis.
Toxicology Research ( IF 2.1 ) Pub Date : 2016-06-06 , DOI: 10.1039/c6tx00111d Rongchang Chen 1 , Guibo Sun 1, 2 , Longpo Yang 3 , Jian Wang 3 , Xiaobo Sun 1, 2
Toxicology Research ( IF 2.1 ) Pub Date : 2016-06-06 , DOI: 10.1039/c6tx00111d Rongchang Chen 1 , Guibo Sun 1, 2 , Longpo Yang 3 , Jian Wang 3 , Xiaobo Sun 1, 2
Affiliation
Salvia miltiorrhiza Bunge is a well-known medicinal plant in China. Salvianolic acid B (Sal B) is the most abundant bioactive compound extracted from the root of S. miltiorrhiza. The present study investigates the effect of Sal B on cardiac function and cardiomyocyte apoptosis in doxorubicin (DOX)-treated mice. After pretreatment with Sal B (2 mg kg-1 iv) for 7 d, male BALB/c mice were injected with a single dose of DOX (20 mg kg-1 ip). The cardioprotective effect of Sal B was observed on the 7th day after DOX treatment. DOX caused retarded body growth, apoptotic damage, and Bcl-2 expression disturbance. In contrast, Sal B pretreatment (2 mg kg-1 iv before DOX administration) attenuated the DOX induced apoptotic damage in heart tissues. Further study indicated that Sal B protected against DOX induced cardiotoxicity, at least, partially, by inhibiting endoplasmic reticulum stress, and by being involved in the PI3K/Akt pathway. These findings clarified the potential of Sal B as a promising reagent for treating DOX induced cardiotoxicity.
更新日期：2019-11-01
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