OBJECTIVE To analyze the clinical, pathological, and sociodemographic aspects between triple-negative breast cancer (TNBC) and non-TNBC in a Brazilian cohort and identify potential prognostic factors. METHODS This hospital-based retrospective cohort study included 447 women with breast cancer treated at referral centers in Southeastern Brazil. Overall and disease-free survival were compared; prognostic factors were evaluated. RESULTS Triple-negative breast cancer corresponded to 19.5% of breast cancer diagnosis and was more prevalent among nonwhite and less educated women. The patients with TNBC tended to present with stage III cancer, high p53 expression, lymphocytic infiltration, and multifocality and treated with radical surgery and chemotherapy. The 5-year overall and disease-free survival were 62.1% and 57.5% for TNBC and 80.8% and 75.3% for non-TNBC, respectively (P < .001). The TNBC recurrence was associated with multicentricity, whereas lymph node involvement increased the risk of both recurrence and death. Non-TNBC worse clinical course was associated with nonwhite ethnicity, lower education level, lymph node involvement, and advanced stage. CONCLUSIONS Triple-negative breast cancer exhibited a more aggressive behavior, earlier and more frequent recurrence, and worse survival compared with non-TNBC. While biological and social variables were associated with poorer prognosis in non-TNBC, only lymph node involvement and multicentricity were correlated with worse clinical outcomes in TNBC.

中文翻译：

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巴西队列中三阴性和非三阴性乳腺癌的生存研究。

目的 分析巴西队列中三阴性乳腺癌 (TNBC) 和非 TNBC 之间的临床、病理和社会人口学方面，并确定潜在的预后因素。方法 这项基于医院的回顾性队列研究包括在巴西东南部转诊中心接受治疗的 447 名乳腺癌女性。比较总生存期和无病生存期；预后因素进行了评估。结果 三阴性乳腺癌占乳腺癌诊断的 19.5%，在非白人和受教育程度较低的女性中更为普遍。TNBC 患者倾向于出现 III 期癌症、高 p53 表达、淋巴细胞浸润和多灶性，并接受根治性手术和化疗。TNBC 的 5 年总生存率和无病生存率分别为 62.1% 和 57.5%，分别为 80.8% 和 75。非 TNBC 分别为 3% (P < .001)。TNBC 复发与多中心性相关，而淋巴结受累增加了复发和死亡的风险。非 TNBC 较差的临床过程与非白人种族、较低的教育水平、淋巴结受累和晚期有关。结论与非 TNBC 相比，三阴性乳腺癌表现出更具侵袭性的行为、更早和更频繁的复发以及更差的生存率。虽然生物学和社会变量与非 TNBC 的较差预后相关，但只有淋巴结受累和多中心性与 TNBC 的较差临床结果相关。非 TNBC 较差的临床过程与非白人种族、较低的教育水平、淋巴结受累和晚期有关。结论与非 TNBC 相比，三阴性乳腺癌表现出更具侵袭性的行为、更早和更频繁的复发以及更差的生存率。虽然生物学和社会变量与非 TNBC 的较差预后相关，但只有淋巴结受累和多中心性与 TNBC 的较差临床结果相关。非 TNBC 较差的临床过程与非白人种族、较低的教育水平、淋巴结受累和晚期有关。结论与非 TNBC 相比，三阴性乳腺癌表现出更具侵袭性的行为、更早和更频繁的复发以及更差的生存率。虽然生物学和社会变量与非 TNBC 的较差预后相关，但只有淋巴结受累和多中心性与 TNBC 的较差临床结果相关。