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Detecting Demyelination by PET: The Lesion as Imaging Target.
Molecular Imaging ( IF 2.8 ) Pub Date : 2018-07-25 , DOI: 10.1177/1536012118785471
Pedro Brugarolas 1 , Daniel S Reich 2 , Brian Popko 3
Affiliation  

Noninvasive imaging of demyelination and remyelination is critical for diagnosis and clinical management of demyelinating diseases. Positron emission tomography (PET) has the potential to complement magnetic resonance imaging (MRI) by providing a quantitative measure specific to demyelination. In Brugarolas et al's study 1 , we describe the development of the first PET tracer for voltage-gated K+ channels based on a clinically approved drug for multiple sclerosis that can be used for imaging demyelination in animal models.

中文翻译:

通过PET检测脱髓鞘:以病变为成像目标。

脱髓鞘和再髓鞘的无创成像对于脱髓鞘疾病的诊断和临床管理至关重要。正电子发射断层扫描(PET)通过提供特定于脱髓鞘的定量措施,具有补充磁共振成像(MRI)的潜力。在Brugarolas等人的研究1中,我们描述了基于临床认可的多发性硬化药物的第一款用于电压门控K +通道的PET示踪剂的开发,该药物可用于动物模型中的脱髓鞘成像。
更新日期:2019-11-01
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